Infectious Disease

GENOME, C-DIFFICILE

A phase II, randomized, open label, multicenter trial of Ramoplanin vs. vancomycin for the treatment of Clostridium difficile associated diarrhea.

WYETH, 307
A randomized study evaluating Tigecycline and Linezolid (Zyvox) for the treatment of selected infections with VRE and evaluating Tigecycline and Vancomycin for the treatment of selected infections with MRSA.

WYETH, 309
A non-comparative study of Tigecycline forthe treatment of gram negative organisms such as Enterobacter, Acinetobacter Baumanni, and Klebsiella pneumonia.

ADDRESS, Eli Lilly
Efficacy and safety of Drotrecogin Alfa (Activated) in adult patients with early stage, severe sepsis.

Oncology

SOUTHWEST ONCOLOGY GROUP S0001
A phase III study to compare survival and toxicities in patients with newly diagnosed glioblastoma multiforme or gliosarcoma when treated with BCNU plus radiation therapy and O6-BG.

SOUTHWEST ONCOLOGY GROUP S0023
A phase III study for stage III-a or III-b unresectable non-small cell lung cancer. Uses chemotherapy with Cisplatin and Etoposide with concurrent radiation therapy.

SOUTHWEST ONCOLOGY GROUP JPR7 
A Phase III trial for prostate cancer. Compares intermittent vs. continuous androgen suppression in patients with rising PSA's occurring after radiation therapy.

MEDIMMUNE ETHYOL SURVEILLANCE STUDY
A study for head and neck or lung cancer patients undergoing radiation therapy. Uses subcutaneous administration of Amifostine (ethyol) daily just prior to radiation therapy.

EPIC
A phase III pharmaceutical-sponsored trial for metastatic colorectal carcinoma patients who have failed first-line therapy. Uses Irinotecan alone or Irinotecan plus Cetuximab (Erbitux), an antibody that blocks epidermal growth factor.

RTOG 0214
A phase III study using prophylactic cranial irradiation vs. observation in patients with locally advanced non-small cell lung cancer.

SOUTHWEST ONCOLOGY GROUP S0124
A randomized phase III trial for newly diagnosed small cell lung cancer patients to receive either Irinotecan and Cisplatin vs. Cisplatin and Etoposide.

EXPLORE
A randomized phase III study of Cetuximab, Oxaliplatin, 5-FU, and Leucovorin vs. Oxaliplatin, 5-FU, and Leucovorin in patients with previously treated colorectal cancer.

CTSU 1899/E1899
A randomized phase III trial for prostate patients with rising PSA levels.

SOUTHWEST ONCOLOGY GROUP S9900
A randomized trial of surgery with or without preoperative Paclitaxel and Carboplatin in patients with stage I-b, II, or III-a non-small cell lung cancer to compare survival and to compare regimens in terms of operative mortality and other toxicities.

MAMMOSITE REGISTRY
Registry of breast cancer patients that have been treated with brachytherapy (radiation) using the MammoSite applicator device. The study looks at overall survival, recurrence, safety, and cosmesis.